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CFR, which represents the maximal dilator response to an arteriolar vasodilator, is frequently applied but carries the disadvantage of representing the effects of macro- and microvascular disease (Wang et al., 2020
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Ten additional disulphide stabilised exendin-4 antibody fusions were produced (Supplementary Table 5) and, following protein A purification, four of these fusions presented a reduction in aggregate formation compared to Ab#2_DSB#1 (Fig